The antonyms for the word "persist with" include words and phrases such as abandon, quit, give up, surrender, and discontinue. These antonyms refer to the act of stopping, ceasing, or relinquishing something that has been previously pursued. They connote a sense of defeat, resignation, or resignation and are often associated with negative outcomes or consequences. An individual who abandons or quits a task might be perceived as lacking perseverance, dedication, or determination. However, in certain situations, giving up might be a wise or pragmatic decision, especially when more pressing or urgent matters demand attention or resources.