The word "most scoundrelly" is a strong adjective that suggests extreme dishonesty, shamelessness or immorality. Some suitable antonyms for this word could be "honorable", "virtuous", "noble" or "upright". These words connote the opposite meanings of most scoundrelly, signifying traits of honesty, integrity, and decency. Other antonyms of most scoundrelly could include "moral", "ethical" or "righteous" which denote a high standard of moral conduct. Overall, these antonyms stand in contrast to the meaning of "most scoundrelly" and help to convey a positive and morally upright connotation.