Antonyms for the word "most favorably" include "unfavorably," "negatively," "disadvantageously," "poorly," and "unsatisfactorily." If something is not viewed "most favorably," then it may be perceived as being unfavorable, disadvantageous, or unsatisfactory. Alternatively, it may be seen as not meeting expectations, failing to achieve desired outcomes, or causing dissatisfaction. Overall, antonyms for "most favorably" suggest a negative connotation that implies that something is not deemed as highly or positively as it could be. It signifies a lack of favor or preference, which may result in negative repercussions or consequences.